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Inotek Pharmaceuticals is a clinical-stage, privately held, biopharmaceutical company focused on the discovery, development and commercialization of novel therapies to treat glaucoma and other serious diseases of the eye.

Glaucoma is a disease of the eye that is typically characterized by structural evidence of optic nerve damage, vision loss and consistently elevated intraocular pressure, or IOP. Our lead product candidate, trabodenoson, is a first-in-class selective adenosine mimetic designed to lower IOP by restoring the eye's natural pressure control mechanism. This molecule was developed to selectively stimulate a particular adenosine subreceptor in the eye with the effect of augmenting the intrinsic function of the eye's trabecular meshwork, or TM, which is the main passageway for transporting the aqueous humor, a liquid that maintains the eye's shape and typically experiences elevated pressure in glaucoma. We believe that by enhancing this naturally occurring TM process, rather than changing the fundamental dynamics of pressure regulation in the eye, trabodenoson's mechanism of action should result in a lower risk of unintended side effects and long term safety or tolerability issues. Additionally, trabodenoson's unique mechanism of action in the TM should complement the activity of existing products that lower IOP by addressing different parts of the in-flow and out-flow system of the eye.

Trabodenoson has completed Phase 2 clinical development in primary open-angle glaucoma (POAG) and ocular hypertensive (OHT) patients and is ready for a registrational Phase 3 program. Trabodenoson, if ultimately approved by regulatory agencies, will be a valuable, innovative product that ophthalmologists can use alone or in combination with other approved medicines for glaucoma, and would also be a new treatment option for those patients who are refractory to current drug therapies.

Inotek, in addition to having built a potential first-in-class ophthalmic product candidate in trabodenoson, has an experienced management team with a track record of multiple successful NDA approvals and successful product launches. Inotek intends to advance its programs through regulatory approval and to market its ophthalmology products, a specialty area, with a relatively small and focused sales and marketing team. The Company is based in Lexington, MA.