Inotek Pharmaceuticals to Present at the Cowen 30th Annual Health Care Conference on Thursday, March 11

Inotek Pharmaceuticals Corp., a clinical-stage drug development company advancing innovative drug candidates to address significant diseases of the eye, with a major focus on glaucoma, today announced that Paul G. Howes, President and CEO, will present a corporate overview at the Cowen and Company 30th Annual Health Care Conference on Thursday March 11, 2010 at 9:30 a.m. Eastern Time. The conference will be held at the Boston Marriott Copley Place Hotel, Boston, MA.

Read more →

Inotek Pharmaceuticals’ Novel Glaucoma Candidate, INO-8875, Significantly Reduces Intraocular Pressure in Phase 1/2 Study

Inotek Pharmaceuticals today announced positive top-line results from a Phase 1/2 randomized, double-blind, placebo-controlled clinical trial of the Company’s lead candidate, INO-8875, in patients with glaucoma. Treatment with INO-8875 was well tolerated and resulted in a statistically significant reduction in intraocular pressure (IOP). Elevated IOP can be a risk factor in the development and progression of optic nerve changes and vision loss associated with glaucoma and is thought to be a causal factor in the neuropathology of the disease. INO-8875 represents a new approach to treating glaucoma patients by increasing the outflow of ocular fluid via the trabecular meshwork, the main pathway used by healthy eyes to maintain normal IOP. “The glaucoma market has not seen the introduction of a therapeutic with a new mechanistic approach for over a decade,” said Paul G. Howes, President and Chief Executive Officer of Inotek. “We believe INO-8875 is an important investigational agent that […]

Read more →

Inotek Pharmaceuticals Presents Preclinical Data in Support of Novel Glaucoma Candidate, INO-8875 at ARVO

Inotek Pharmaceuticals today presented positive preclinical results supporting the Company’s lead clinical-stage drug candidate in glaucoma, INO-8875. INO-8875 is a highly selective adenosine-1 (A1) receptor agonist in development as a topical agent for the treatment of elevated intraocular pressure (IOP) associated with primary open angle glaucoma and ocular hypertension. Elevated IOP can be a risk factor in the development and progression of optic nerve changes and vision loss associated with glaucoma and is thought to be a causal factor in the neuropathology of the disease. Results from preclinical studies of INO-8875 were presented in a poster presentation at the Association for Research in Vision and Ophthalmology, Inc. (ARVO) 2009 Annual Meeting in Fort Lauderdale, FL. “Today’s results directly support our ongoing Phase 1/2 clinical study of INO-8875 in glaucoma and more broadly validate Inotek’s growing ophthalmology pipeline which is focused on the development of therapeutics with novel mechanisms of action […]

Read more →

Inotek Pharmaceuticals to Present at Cowen and Company’s 36th Annual Health Care Conference

LEXINGTON, Mass.—(BUSINESS WIRE)—Feb. 29, 2016—Inotek Pharmaceuticals Corporation (NASDAQ: ITEK), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for ocular diseases, today announced that David P. Southwell, President and Chief Executive Officer of Inotek, will present at Cowen and Company’s 36th Annual Health Care Conference on Monday, March 7th, 2016 at 2:00 ET at the Boston Marriott Copley Place Hotel in Boston. A live audio webcast of the presentation will be available on the Investors section of the company’s website, www.inotekpharma.com. A replay of the presentation will be archived on the Inotek website following the conference. About Inotek Pharmaceuticals Corporation Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. The Company’s lead product candidate, trabodenoson, is a first-in-class selective adenosine mimetic currently in Phase 3 development. Trabodenoson was developed in Inotek’s laboratories and is […]

Read more →

Patents Issue for Inotek Pharmaceuticals’ Lead Clinical Candidates in Glaucoma and Contrast-Induced Nephropathy

Inotek Pharmaceuticals Corporation announced today that the United States Patent and Trademark Office has issued two new patents covering the Company’s two lead clinical compounds. US Patent number 7,423,144 relates to INO-8875, in clinical development as a novel treatment for glaucoma and US Patent number 7,432,369 relates to INO-4885, in clinical development for the prevention of contrast-induced nephropathy. “These patents cover important technology discovered and developed by Inotek scientists and serve as an initial foundation for our growing pipeline in ophthalmology and other select indications with significant unmet medical need,” said Paul G. Howes, President & Chief Executive Officer of Inotek. INO-8875 is a selective adenosine 1 agonist in Phase 1 clinical development as a topical agent for the treatment of elevated intraocular pressure associated with primary open angle glaucoma and ocular hypertension. Adenosine 1 receptors have been shown to play a role in reducing intraocular pressure by increasing the […]

Read more →

Inotek Commences Phase 1 Trial in Glaucoma with Selective Adenosine 1 (A1) Agonist

BEVERLY, Mass., June 18, 2008 – Inotek Pharmaceuticals Corporation announced today that it has begun enrollment in a Phase 1 clinical trial with the Company’s selective Adenosine 1 agonist, INO-8875, for the treatment of glaucoma. In March, Inotek received approval from the U.S. Food and Drug Administration to advance INO-8875 into clinical trials. The initial study will evaluate the safety, tolerability, and the potential of INO-8875 to lower intraocular pressure (IOP) in glaucoma patients. Glaucoma patients typically have elevated levels of IOP which can damage the optic nerve of the eye and lead to partial or complete loss of vision. “We are pleased that our clinical program in glaucoma is progressing and I am encouraged by the strength of our preclinical data supporting the potential role of Adenosine 1 receptor agonists in managing intraocular pressure,” said Dr. Rudolf Baumgartner, Inotek’s Chief Medical Officer. “New mechanisms for lowering IOP are needed […]

Read more →

Inotek Pharmaceuticals’ Novel Glaucoma Candidate, INO-8875, Selected for Presentation at the ARVO 2009 Annual Meeting

Inotek Pharmaceuticals today announced that preclinical data supporting the Company’s lead clinical-stage drug candidate in glaucoma, INO-8875, will be presented in a poster session at the Association for Research in Vision and Ophthalmology, Inc. (ARVO) 2009 Annual Meeting in Fort Lauderdale, FL. INO-8875 is a highly selective adenosine-1 receptor agonist currently completing a Phase 1/2 trial as a topical agent for the treatment of elevated intraocular pressure (IOP) associated with primary open angle glaucoma and ocular hypertension. The preclinical data suggests that INO-8875 lowers IOP primarily by restoring trabecular meshwork outflow, the most important outflow pathway to maintain IOP in healthy eyes. Additionally, INO-8875 may have a secondary mechanism of action to decrease IOP by reducing aqueous humor production. Norman Kim, M.S., DABT, Senior Director, Preclinical Development at Inotek will present the results of Abstract #4061/A223 entitled “INO-8875, An Adenosine A1 Agonist, in Development for Open-Angle Glaucoma Reduces IOP in […]

Read more →