Inotek Pharmaceuticals Corp., a clinical-stage drug development company advancing innovative drug candidates to address significant diseases of the eye, with a major focus on glaucoma, today announced that Paul G. Howes, President and CEO, will present a corporate overview at the Cowen and Company 30th Annual Health Care Conference on Thursday March 11, 2010 at 9:30 a.m. Eastern Time. The conference will be held at the Boston Marriott Copley Place Hotel, Boston, MA.

Inotek Pharmaceuticals today announced positive top-line results from a Phase 1/2 randomized, double-blind, placebo-controlled clinical trial of the Company’s lead candidate, INO-8875, in patients with glaucoma. Treatment with INO-8875 was well tolerated and resulted in a statistically significant reduction in intraocular pressure (IOP). Elevated IOP can be a risk factor in the development and progression of optic nerve changes and vision loss associated with glaucoma and is thought to be a causal factor in the neuropathology of the disease. INO-8875 represents a new approach to treating glaucoma patients by increasing the outflow of ocular fluid via the trabecular meshwork, the main pathway used by healthy eyes to maintain normal IOP. “The glaucoma market has not seen the introduction of a therapeutic with a new mechanistic approach for over a decade,” said Paul G. Howes, President and Chief Executive Officer of Inotek. “We believe INO-8875 is an important investigational agent that […]

Inotek Pharmaceuticals today presented positive preclinical results supporting the Company’s lead clinical-stage drug candidate in glaucoma, INO-8875. INO-8875 is a highly selective adenosine-1 (A1) receptor agonist in development as a topical agent for the treatment of elevated intraocular pressure (IOP) associated with primary open angle glaucoma and ocular hypertension. Elevated IOP can be a risk factor in the development and progression of optic nerve changes and vision loss associated with glaucoma and is thought to be a causal factor in the neuropathology of the disease. Results from preclinical studies of INO-8875 were presented in a poster presentation at the Association for Research in Vision and Ophthalmology, Inc. (ARVO) 2009 Annual Meeting in Fort Lauderdale, FL. “Today’s results directly support our ongoing Phase 1/2 clinical study of INO-8875 in glaucoma and more broadly validate Inotek’s growing ophthalmology pipeline which is focused on the development of therapeutics with novel mechanisms of action […]